Atlas Labs Bio products are sold for laboratory research use only — not for human or animal consumption, and not intended to diagnose, treat, cure, or prevent any disease. Must be handled only by qualified researchers, in accordance with all applicable laws. See the full Research Disclaimer page for complete terms.
MOTS-c
≥98% Purity Research Use OnlyPrice range: $45.99 through $85.99
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, one of the mitochondrial-derived peptides. Supplied as a lyophilized powder for laboratory research use only.
Description
What is MOTS-c?
MOTS-c, short for mitochondrial open reading frame of the 12S rRNA type-c (CAS 1627580-64-6, molecular formula C101H152N28O22S2, molecular weight 2174.6 g/mol), is a 16-amino-acid peptide. It is encoded by a short open reading frame within the mitochondrial 12S rRNA gene.[1]
Research background
MOTS-c was first described in 2015 in Cell Metabolism, in a study characterizing it in cell and mouse models.[1] Later reviews describe it as acting mainly through the folate-AICAR-AMPK pathway.[2]
Format and documentation
Atlas Labs Bio supplies MOTS-c as a white to off-white lyophilized powder in sealed glass vials at 10 mg and 40 mg. Every batch is tested by an independent third-party laboratory, and the certificate of analysis for the batch currently shipping is linked on this page and in the COA Library.
Storage: Store at 2-8°C.
Frequently asked questions
Where is MOTS-c encoded?
In the mitochondrial genome, within the 12S rRNA gene.[1]
How long is MOTS-c?
16 amino acids.[1]
Can MOTS-c be used by people?
No. Atlas Labs Bio products are sold strictly for laboratory research use and are not for human or animal consumption.
References
- “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism, 2015. PMID 25738459.
- “Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.” Journal of Translational Medicine, 2023. PMID 36670507.
Additional information
| Strength | 10 mg, 40 mg |
|---|
Properties
- CAS Number
- 1627580-64-6
- Synonyms
- Mitochondrial-derived peptide MOTS-c, Mitochondrial ORF of the 12S rRNA type-c
- Molecular Formula
- C101H152N28O22S2
- Molecular Weight
- 2174.6 g/mol
- Physical Appearance
- White to off-white lyophilized powder
- Terms
- Atlas Labs Bio products are sold for laboratory research use only — not for human or animal consumption, and not intended to diagnose, treat, cure, or prevent any disease. Must be handled only by qualified researchers, in accordance with all applicable laws. See the full Research Disclaimer page for complete terms.
Certificate Of Analysis
Current Batch
Select a strength above to view its Certificate of Analysis.
2D Structure
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