Atlas Labs Bio products are sold for laboratory research use only — not for human or animal consumption, and not intended to diagnose, treat, cure, or prevent any disease. Must be handled only by qualified researchers, in accordance with all applicable laws. See the full Research Disclaimer page for complete terms.
FOXO4-DRI
≥98% Purity Research Use Only$119.99
FOXO4-DRI is a synthetic D-retro-inverso peptide designed to interfere with the interaction between the FOXO4 and p53 proteins, studied in cellular senescence research. Supplied as a lyophilized powder for laboratory research use only.
Description
What is FOXO4-DRI?
FOXO4-DRI is a synthetic peptide built from D-amino acids in retro-inverso order (CAS 2460055-10-9, molecular formula C228H388N86O64, molecular weight 5358.05 g/mol). It was designed to disrupt the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53.[1]
Research background
FOXO4-DRI was described in a 2017 study in Cell, which reported that disrupting the FOXO4-p53 interaction caused p53 nuclear exclusion and apoptosis selectively in senescent cells, in cell and mouse models.[1] A 2025 follow-up study identified the disordered p53 transactivation domain as the target of FOXO4 and of FOXO4-DRI.[2]
Format and documentation
Atlas Labs Bio supplies FOXO4-DRI as a white to off-white lyophilized powder in a sealed 10 mg glass vial. Third-party certificates of analysis for Atlas Labs Bio products are published in the COA Library.
Storage: Store at 2-8°C.
Frequently asked questions
What does “DRI” mean?
D-retro-inverso: the peptide is made from D-amino acids in reversed sequence order, a design commonly used to make peptides more resistant to enzymatic breakdown.
What interaction does FOXO4-DRI target?
The interaction between FOXO4 and p53.[1][2]
Can FOXO4-DRI be used by people?
No. Atlas Labs Bio products are sold strictly for laboratory research use and are not for human or animal consumption.
References
Properties
- CAS Number
- 2460055-10-9
- Synonyms
- Proxofim, FOXO4 D-Retro-Inverso peptide
- Molecular Formula
- C228H388N86O64
- Molecular Weight
- 5358.05 g/mol
- Physical Appearance
- White to off-white lyophilized powder
- Terms
- Atlas Labs Bio products are sold for laboratory research use only — not for human or animal consumption, and not intended to diagnose, treat, cure, or prevent any disease. Must be handled only by qualified researchers, in accordance with all applicable laws. See the full Research Disclaimer page for complete terms.
Certificate Of Analysis
Current Batch
The certificate of analysis for the current batch is being prepared and will be published here.
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