Atlas Labs Bio products are sold for laboratory research use only — not for human or animal consumption, and not intended to diagnose, treat, cure, or prevent any disease. Must be handled only by qualified researchers, in accordance with all applicable laws. See the full Research Disclaimer page for complete terms.
CJC-1295
≥98% Purity Research Use Only$34.99
CJC-1295 without DAC, also known as Modified GRF (1-29), is a synthetic 29-amino-acid analog of growth hormone-releasing factor with substitutions that improve its stability. Supplied as a lyophilized powder for laboratory research use only.
Description
What is CJC-1295 without DAC?
CJC-1295 without DAC, also referenced as Modified GRF (1-29) or Mod GRF 1-29 (CAS 446262-90-4, molecular formula C152H252N44O42, molecular weight 3367.9 g/mol), is a synthetic analog of the first 29 amino acids of human growth hormone-releasing factor. It shares the modified GRF(1-29) peptide sequence of CJC-1295 but lacks the albumin-binding drug affinity complex (DAC).[1]
Research background
Native GRF is rapidly inactivated by the plasma enzyme dipeptidyl peptidase IV (DPP-IV), which cleaves its Ala2-Asp3 bond. Amino acid substitutions at position 2 have been studied as a way to improve GRF analog stability against this cleavage.[2]
Format and documentation
Atlas Labs Bio supplies CJC-1295 without DAC as a white to off-white lyophilized powder in a sealed 5 mg glass vial. Third-party certificates of analysis for Atlas Labs Bio products are published in the COA Library.
Storage: Store at 2-8°C.
Frequently asked questions
Is CJC-1295 without DAC the same as Mod GRF 1-29?
Yes. Both names refer to the same modified GRF(1-29) peptide.
What is the difference from CJC-1295 with DAC?
The DAC version adds a reactive group that binds serum albumin.[1] See CJC-1295 with DAC.
Can CJC-1295 be used by people?
No. Atlas Labs Bio products are sold strictly for laboratory research use and are not for human or animal consumption.
References
- “Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.” Endocrinology, 2005. PMID 15817669.
- “Position 2 and position 2/Ala15-substituted analogs of bovine growth hormone-releasing factor (bGRF) with enhanced metabolic stability and improved in vivo bioactivity.” Journal of Medicinal Chemistry, 1993. PMID 8464043.
Properties
- CAS Number
- 446262-90-4
- Synonyms
- CJC-1295 without DAC, Modified GRF (1-29), Mod GRF 1-29, CJC-1295 no DAC
- Molecular Formula
- C152H252N44O42
- Molecular Weight
- 3367.9 g/mol
- Physical Appearance
- White to off-white lyophilized powder
- Terms
- Atlas Labs Bio products are sold for laboratory research use only — not for human or animal consumption, and not intended to diagnose, treat, cure, or prevent any disease. Must be handled only by qualified researchers, in accordance with all applicable laws. See the full Research Disclaimer page for complete terms.
Certificate Of Analysis
Current Batch
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